What is not visible outwardly, before the dog reaches heart failure, is enlargement of the heart. As greater quantities of blood leak through the damaged mitral valve from the left ventricle back into the left atrium of the heart, the atrium gradually begins to swell and enlarge (see x-ray of a severely enlarged heart, at right) -- called myocardial remodeling -- to accommodate the overload of blood, and there is a reduction in the ability of the ventricle to provide sufficient blood to meet the demands of the rest of the body. The heart then has to pump harder and faster, to meet those demands. The shut-down of the distant blood vessels also has the effect of causing the left ventricle to beat against a higher resistance, causing another increase in mitral valve leakage.
A library of many thousands of user specified lift profiles can be established by the user for use in their engine test programs. From this library the user can select up to 128 lift profiles, that can be applied to any engine valve, for use in any given engine test session and each of these profiles can also be phase advanced or retarded +/- 128 degrees. If required, whilst the engine is running, a lift profile may be changed or modified every engine cycle and can contain as many lift events as are physically possible to implement. For example an engine can be configured to swap between two and four stroke combustion on alternate cycles if required. This allows the user to change a profile quickly and to observe its effects on exhaust emissions and engine performance, using standard test cell monitoring equipment. For a four stroke cycle a lift demand is specified as 720 lift points. ie. one lift increment for every degree of crankshaft rotation.
The Steam client includes a digital storefront called the Steam Store through which users can purchase computer games. Once the game is bought, a software license is permanently attached to the user's Steam account, allowing him or her to download the software on any compatible device. Game licenses can be given to other accounts under certain conditions. Content is delivered from an international network of servers using a proprietary file transfer protocol .  Steam sells its products in US and Canadian dollars, euros, pounds sterling , Brazilian reais , Russian rubles , Indonesian rupiah and Indian rupees  depending on the user's location.  From December 2010, the client supports the Webmoney payment system, which is popular in many European, Middle Eastern, and Asian countries.  Starting in April 2016, Steam began accepting payments in Bitcoin , valued based on the user's geolocation, with transactions handled by BitPay .  The Steam storefront validates the user's region; the purchase of titles may be restricted to specific regions because of release dates, game classification, or agreements with publishers. Since 2010, the Steam Translation Server project offers Steam users to assist with the translation of the Steam client, storefront, and a selected library of Steam games for twenty-seven languages.  Steam also allows users to purchase downloadable content for games, and for some specific game titles such as Team Fortress 2 , the ability to purchase in-game inventory items. In February 2015, Steam began to open similar options for in-game item purchases for third-party games.